Corticosteroids as adjunctive therapy in the treatment of influenza

L Lansbury, C Rodrigo, J Leonardi‐Bee… - Cochrane Database …, 2019 - cochranelibrary.com
Cochrane Database of Systematic Reviews, 2019cochranelibrary.com
Background Specific treatments for influenza are limited to neuraminidase inhibitors and
adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions,
most likely due to their anti‐inflammatory and immunomodulatory properties. Although
commonly prescribed for severe influenza, there is uncertainty over their potential benefits or
harms. This is an update of a review first published in 2016. Objectives To systematically
assess the effectiveness and potential adverse effects of corticosteroids as adjunctive …
Background
Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti‐inflammatory and immunomodulatory properties. Although commonly prescribed for severe influenza, there is uncertainty over their potential benefits or harms. This is an update of a review first published in 2016.
Objectives
To systematically assess the effectiveness and potential adverse effects of corticosteroids as adjunctive therapy in the treatment of influenza, taking into account differences in timing and doses of corticosteroids.
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